Technologies
smartSET™
A Breakthrough in Pulse Oximetry
Featuring AFib and AI-Enabled OIRD Detection Algorithms
smartSET is a first-of-its-kind pulse oximetry platform that uses pattern recognition to help clinicians detect key clinical events, providing actionable insights that go above and beyond traditional pulse oximetry monitoring.
The Next Evolution of Pulse Oximetery
Moving from Measurement to Detection
Building on industry-leading Masimo SET® technology and more than 35 years of signal processing innovation, smartSET expands pulse oximetry from measuring individual parameters to detecting key clinical events.*
Designed to Provide:
Earlier Clinical Insight
Identifies physiological changes associated with AFib and OIRD to facilitate earlier intervention.
Peace of Mind
Provides confidence that patients are being continuously monitored for key clinical events.
Enhanced Workflow
Expands clinical value by leveraging existing workflows.
* smartSET sensors unlock the PPG AFib and OIRD Detection features, which are currently available only on Radius VSM® wearable devices.
Earlier Insight into Atrial Fibrillation (AFib)
AFib at a Glance
Atrial fibrillation is common and often undiagnosed.
>10% of patients
over age 65 have AFib1
>60% of patients
were unaware before diagnosis2
3-5x
higher risk of stroke3
Early Treatment Makes a Difference
Treating AFib within a year of diagnosis has been shown to
reduce the risk of stroke by 34%4
PPG AFib with smartSET
smartSET continuously analyzes pulse waveform data to identify rhythms suggestive of AFib, helping clinicians gain earlier insight and determine when further ECG or telemetry evaluation is needed to diagnose AFib, potentially optimizing use.
PPG AFib Performance
PPG AFib with smartSET detects rhythms suggestive of AFib with high sensitivity and specificity.5
97.0% Sensitivity5
Irregular Beat-to-Beat Interval
100.0% Specificity5
Irregular Beat-to-Beat Interval and Absence of P-waves
Helping Clinicians Recognize and Respond to OIRD
Opioid-induced respiratory depression (OIRD) is difficult to detect, and severe events can be costly.
+30%
increased length of stay6
1 in 10
surgical patients have opioid-related adverse events, with ~50% of these events classified as respiratory episodes6
+$8,000 per patient
increased cost6
OIRD Detection with smartSET
smartSET continuously analyzes oxygen saturation, pulse rate, and perfusion index in real time to identify physiological patterns associated with OIRD—supporting earlier intervention through escalating visual or audible alarms.
AI-Powered Multi-Signal Analysis
Oxygen Saturation*
Pulse Rate*
Perfusion Index
* Masimo SET® Measure-through motion technology includes SpO2 and PR.
Real-World Case: OIRD Detection in Action
Hospital staff monitored SpO2 and PR but did not have visibility to OIRD alarms.
The recorded data show that smartSET would have generated escalating OIRD alarms before clinical intervention, suggesting that earlier intervention could have been possible for this patient receiving patient-controlled analgesia (PCA).
Built on Clinically Proven Masimo SET®
smartSET is built on the same SpO2 platform trusted by clinicians worldwide.
200 million+ patients are monitored by Masimo SET® pulse oximetry each year.7
All top 10 U.S. hospitals use Masimo SET® as their primary pulse oximetry technology.8
Schedule an Evaluation
See how smartSET can make a difference in your healthcare organization. Please fill out the following information and a Masimo representative will be in touch with you.
Turakhia MP et al. PloS One. 2018;13(4):e0195088
AHA. New research finds 62% of AFib patients were unaware of the condition before diagnosis. Published Sept. 3, 2025. Accessed: 6/17/2026
Heart&Stroke. Atrial fibrillation. Accessed 7/24/2026
Dickow J, et al. J Am Heart Assoc. 2022;11(11):e024214.
Masimo data on file.
Shafi S et al. JAMA Surg. 2018;153(8):757-763.
Estimate: Masimo data on file.
As ranked in the 2026 Newsweek World’s Best Hospitals listing: https://rankings.newsweek.com/ worlds-best-hospitals-2026/united-states-america.
Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. See instructions for use for full prescribing information, including indications, contraindications, warnings, and precautions.
PLCO-008365/PLM-15654A-1026